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    <ns5:termsAndConditions xml:lang="en">The RECIPIENT of BIOLOGICAL RESOURCE shall prior inform the DEPOSITOR of the purpose of the use of the BIOLOGICAL RESOURCE.  The RECIPIENT agrees to use the BIOLOGICAL RESOURCE only for publication of research papers.  The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.</ns5:termsAndConditions>
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    <ns0:brs_depositorOrganization xml:lang="ja">東北大学</ns0:brs_depositorOrganization>
    <ns0:brs_depositorOrganization xml:lang="en">Tohoku Univ.</ns0:brs_depositorOrganization>
    <ns0:brs_depositor xml:lang="ja">菅村　和夫</ns0:brs_depositor>
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    <ns1:donorDNA>phage P1 loxP sites, mouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, mouse STAM1 and STAM2 genomic DNA</ns1:donorDNA>
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    <dc:description xml:lang="ja">STAM1 floxed、STAM2 KO2重変異マウス。T細胞特異的 (Lck-Cre Tg) にSTAM1flox/floxとSTAM2-/-を2重欠損させるとT細胞分化異常を呈し、成熟T細胞が欠損する。,</dc:description>
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    <ns0:brs_depositor xml:lang="en">Kazuo SUGAMURA</ns0:brs_depositor>
    <ns1:strainDevelopment xml:lang="ja">東北大学大学院医学系研究科・菅村和夫先生（2001）。C57BL/6N背景（N7以上）。</ns1:strainDevelopment>
    <ns5:termsAndConditions xml:lang="ja">条件を付加する。&lt;br&gt;利用者は事前に寄託者に利用の報告をする。公表を前提とした学術研究に限る。利用者が当該リソースを使用した研究成果に基づく特許等の申請を行う場 合は、寄託者と別途協議を行う。</ns5:termsAndConditions>
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    <ns1:strainDevelopment xml:lang="en">Developed by Kazuo Sugamura, Tohoku University Graduate School of Medicine.  The mutant mice were backcrossed to C57BL/6N over 7 times.</ns1:strainDevelopment>
    <ns5:addinfo>Necessary documents for ordering:&lt;ol&gt;&lt;li&gt;Order form (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;li&gt;Category I MTA: MTA for distribution with RIKEN BRC (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;li&gt;Acceptance of responsibility for living modified organism (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;/ol&gt;</ns5:addinfo>
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    <ns5:addinfo>&lt;a href='https://brc.riken.jp/mus/pcr00673'&gt;Genotyping protocol -PCR-&lt;/a&gt;</ns5:addinfo>
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    <skos:altLabel xml:lang="ja">B6.Cg-Stam&lt;tm2Sug&gt; Stam2&lt;tm1Sug&gt;</skos:altLabel>
    <skos:altLabel xml:lang="en">B6.Cg-Stam&lt;tm2Sug&gt; Stam2&lt;tm1Sug&gt;</skos:altLabel>
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    <dc:description xml:lang="ja">STAM1 floxed、STAM2 KO2重変異マウス。T細胞特異的 (Lck-Cre Tg) にSTAM1flox/floxとSTAM2-/-を2重欠損させるとT細胞分化異常を呈し、成熟T細胞が欠損する。</dc:description>
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    <ns5:application>Cre/loxP system</ns5:application>
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    <ns1:colonyMaintenance xml:lang="en">Stam: Homozygote x Homozygote [or Crossing to C57BL/6NCrSlc]; Stam2: Homozygote x Homozygote [or Crossing to C57BL/6NCrSlc]</ns1:colonyMaintenance>
    <ns1:colonyMaintenance xml:lang="ja">Stam: Homozygote x Homozygote [or Crossing to C57BL/6NCrSlc]; Stam2: Homozygote x Homozygote [or Crossing to C57BL/6NCrSlc]</ns1:colonyMaintenance>
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